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Chloroethylnitrosoureas (CENUs) were an important family of anticancer agents in the clinical treatment of human malignancies. Several lines of evidences indicated that their cytotoxicity was related to the interstrand crosslink of DNA. In this study, a method for the determination of DNA crosslink was established using real-time fluorescence quantitative PCR. The DNA crosslink ratio induced by two...
According to the results of quantitative pattern recognition for 153 N-nitroso compounds (NNCs) based on Di-region theory, it is put forward that the esters formed from the metabolism of NNCs on beta- or gamma-position could be alkylating agents of DNA bases with the anchimeric assistance of the N-nitroso group. This viewpoint, combined with the conception of alpha-metabolism activation, can explain...
N-phosphorylamino acids can react to form esters, peptides, phosphoryl ester-exchanged products and phosphoryl group migration products under mild conditions which are very important in researches on the origin of life. It has been proposed that the penta-coordinate phosphorous compounds might be the common intermediates of these reactions, which are the key factor to determine the activities. In...
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