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Background
Promoter methylation of tumour suppressor genes (TSGs) has recently been implicated in the pathogenesis of several types of cancer. Regarding melanoma, over 100 genes that contribute to its pathogenesis have been identified to be aberrantly hypermethylated.
Objectives
This is a retrospective observational study that aims to analyse the prevalence of CpG island methylation in a series...
Aim
To assess the accuracy of magnetic resonance enterography in predicting the extension, location and characteristics of the small bowel segments affected by Crohn's disease.
Method
This is a prospective study including a consecutive series of 38 patients with Crohn's disease of the small bowel who underwent surgery at a specialized colorectal unit of a tertiary hospital. Preoperative magnetic...
As the number of existing software systems increases, it also does the number of software engineers involved in the maintenance of large existing systems. Maintenance projects are becoming more usual than new software developments. For this reason, Computer Science education should also consider the development of abilities to deal with large existing software systems. This paper describes an approach...
Currently, software architecture is presented as a solution for the design and development of complex and large software systems. One of the main advantages of the use of software architectures is reuse [1]. Software architectures allow us to reuse software at different levels of abstraction (simple components, architectural styles, etc.) for different purposes (general and domainspecific). Reuse...
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