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We developed a novel lab-on-a-chip device for immunoassays that use paramagnetic bead as the solid carrier of biomolecules. The device combines interdigitated electrodes (IDEs), as the biomolecule detection element, with an array of patterned soft magnetic materials (e.g. NiFe stripes or pads), as the bead manipulation element. The purpose of magnetic bead manipulation is to provide sample preconcentration...
This article summarizes improvements to the speed, simplicity and versatility of tapping mode atomic force microscopy (AFM). Improvements are enabled by a piezoelectric microcantilever with a sharp silicon tip and a thin, low-stress zinc oxide (ZnO) film to both actuate and sense deflection. First, we demonstrate self-sensing tapping mode without laser detection. Similar previous work has been limited...
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