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Purpose: Telemedicine systems must provide clinical data of sufficient quality (according to medical standards) to support safe treatment guidance of outpatients. Quality of clinical data (QoD) typically varies due to unstable performance of ICT-components of these telemedicine systems. Therefore, telemedicine systems that support treatment guidance of outpatients should be QoD-aware and must be able...
Galectins regulate many cell functions important for placental development, however, the localization and role of galectin-7 is unknown. We hypothesized galectin-7 would be expressed by the placenta and detected in serum. Galectin-7 immunolocalized to syncytiotrophoblast, extravillous trophoblast and glandular epithelium in 1st trimester placenta/decidua and to syncytiotrophoblast and endothelial...
Trophoblast growth and invasion of the uterine endometrium are critical events during placentation and are tightly regulated by locally produced factors. Abnormal placentation can result in early miscarriage or preeclampsia and intrauterine growth restriction, leading to impaired fetal and/or maternal health. Chondroitin sulfate proteoglycan 4 (CSPG4) is involved in cancer cell migration and invasion,...
Service-Oriented Computing (SOC) builds upon the intuitive notion of service already known and used in our society for a long time. SOC-related approaches are based on computer-executable functional units that often represent automation of services that exist at the social level, i.e., services at the level of human or organizational interactions. With the increasing adoption of SOC, more complex...
The benefits of service composition are being largely acknowledged in the literature nowadays. However, as the amount of available services increases, it becomes difficult to manage, discover, select and compose them, so that automation is required in these processes. This can be achieved by using semantic information represented in ontologies. Currently there are many different approaches that support...
A pragmatic and straightforward approach to semantic service discovery is to match inputs and outputs of user requests with the input and output requirements of registered service descriptions. This approach can be extended by using pre-conditions, effects and semantic annotations (meta-data) in an attempt to increase discovery accuracy. While on one hand these additions help improve discovery accuracy,...
Although behavior modeling should play a central role in model-driven application development, it is still unclear how behavior modeling should be incorporated in model transformations. This paper presents an MDA-based approach that incorporates behavior modeling at the platform-independent model (PIM) level of the design process of a specific category of applications, i.e., context-aware mobile applications...
The design of distributed applications is a complex undertaking, especially if the designers are forced to immediately deal with the detailed behaviour of the underlying middleware. It would be better if the designers could first focus on the essentials of the applications using suitable abstractions of interaction mechanisms that are provided by communication middleware. In this paper we present...
Methods for enterprise architecture, such as TOGAF, acknowledge the importance of requirements engineering in the development of enterprise architectures. Modelling support is needed to specify, document, communicate and reason about goals and requirements. Current modelling techniques for enterprise architecture focus on the products, services, processes and applications of an enterprise. In addition,...
Service-Oriented Computing allows new applications to be developed by using and/or combining services offered by different providers. Service discovery and composition are performed aiming to comply with the clientpsilas request in terms of functionality and expected outcome. In this paper we present a framework for dynamic service discovery and composition. This framework is based on goals and tasks...
Health monitoring and healthcare provisioning at home (i.e., outside the hospital) have received increasingly attention as a possible and partial solution for addressing the problems of an aging population. There are still many technological issues that need to be solved before home healthcare systems can be really cost-effective and efficient. However, in this paper we will highlight another category...
Service-oriented computing allows new applications to be developed by using and/or combining services offered by different providers. In several cases a service needs sensitive information from the clients in order to execute. The existence of a trust relationship between the client and the provider determines which restrictions the service has concerning the use of this information by the service...
Context-aware service platforms use context information to customize their services to the current users' situation. Due to technical limitations in sensors and context reasoning algorithms, context information does not always represent accurately the reality, and Quality of Context (QoC) models have been proposed to quantify this inaccuracy. The problems we have identified with existing QoC models...
In previous work we have proposed a rule-based platform to support context-aware service development. Rules are used to detect relevant situations in the users' context and to trigger actions in response to context changes. Rule-based solutions offer flexibility with respect to service maintainability, since rules can be modified and added at runtime. However, rule-based systems are often criticized...
Service-oriented architecture (SOA) claims to facilitate the construction of flexible and loosely coupled business applications, and therefore is seen as an enabling factor for enterprise interoperability. The concept of service, which is central to SOA, is very convenient to address the matching of needs and capabilities in enterprise collaborations. In order to satisfy more demanding needs or to...
Although service-oriented architectures offer real benefits when pursuing application integration and business flexibility, there are still no satisfactory solutions for dealing with existing systems that need to cooperate while their services have no perfect match. In the case of incompatible services, a 'mediator' may be introduced which resolves (semantic) interoperability problems by intervening...
Context-aware service platforms use context-aware policy management solutions to manage user's privacy preferences, to manage trust relationships, and to control access to the platform resources. However, existing context-aware policy management solutions focus on at most one policy management area (e.g. trust management, or privacy, or access control) and are difficult to integrate due to their unrelated...
The process of composing a service from other services typically involves multiple models. These models may represent the service from distinct perspectives, e.g., to model the different roles of systems involved in the service, and at distinct abstraction levels, e.g., to model the service's capability, interface or the orchestration that implements the service. The consistency among these models...
Aligning adequately business requirements and software functionality as well as achieving 'loose coupling' for service functionalities, are identified challenges relevant to service-oriented software design. Furthering previous related work, we propose in this paper an application design process that, taking the above challenges into account, addresses systematically and separately business requirements,...
The paper describes the use of APL (a programming language) for the specification of a hardware architecture, the description of an initial implementation algorithm, its verification and controlled transformation to a logic design. Because of its power of expression, APL can be used effectively in each of these design domains. The APL interpreter turns any description into an executable prototype...
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