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Enhanced tissue permeability resulting from pulsed high intensity focused ultrasound (pHIFU) has been studied for over a decade now. Most of these studies have been in mouse models. To proceed to the clinic, two questions remain to be answered, first, what is the mechanism of action, and second, can it be scaled to humans. The goal of our ongoing research is to provide clear answers to these questions...
Finite element simulations have been performed for the dynamics of heating and cooling of a single spherical gold nanoparticle and surrounding fluid environment by laser pulses of nanosecond duration in the limit of validity of Mie theory. Thermal and dielectric property changes of the surrounding medium are taken into account in the model. It has been shown that such changes significantly affect...
The mechanism behind pulsed high intensity focused ultrasound (pHIFU) effects leading to increased drug delivery is currently poorly understood. In this work, the thermal dose and peak temperatures associated with a typical pHIFU treatment were measured in mouse muscle. A non-ultrasonic hyperthermia (HT) treatment was then applied, designed to mimic the thermal component of the pHIFU treatment. The...
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