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The aim of this study was to develop a novel in vivo corneal model of fibrosis in dogs utilizing alkali burn and determine the ability of suberanilohydroxamic acid (SAHA) to inhibit corneal fibrosis using this large animal model. To accomplish this, we used seven research Beagle dogs. An axial corneal alkali burn in dogs was created using 1 N NaOH topically. Six dogs were randomly and equally assigned...
The importance of the internet-of-things (IOT) is now an established reality. With that backdrop, the phenomenal emergence of cameras/sensors mounted on unmanned aerial, ground and marine vehicles (UAVs, UGVs, UMVs) and body worn cameras is a notable new development. The swarms of cameras and real-time computing thereof are at the heart of new technologies like connected cars, drone-based city-wide...
Physiological properties of blood flow at the microvasculature scale can be measured by tracking the movement and density of red blood cells (RBCs). In this paper we propose a method for individual RBC segmentation to enable tracking and capturing dynamically varying bulk transport properties. RBCs have varying annular and disk like morphologies, and are often clustered into clumps that are difficult...
Indirect immunofluorescence (IIF) imaging is a method used for detection of antinuclear auto-antibodies (ANA) for the diagnosis of autoimmune diseases. We present a feature extraction and classification scheme to classify the fluorescence staining patterns of HEp-2 cells in IIF images. We propose a set of complementary features that are sensitive to staining pattern variations among classes. Our feature...
Very large format video or wide-area motion imagery (WAMI) acquired by an airborne camera sensor array is characterized by persistent observation over a large field-of-view with high spatial resolution but low frame rates (i.e. one to ten frames per second). Current WAMI sensors have sufficient coverage and resolution to track vehicles for many hours using just a single airborne platform. We have...
Fluorescently tagged proteins such as GFP-PCNA produce rich dynamically varying textural patterns of foci distributed in the nucleus. This enables the behavioral study of sub-cellular structures during different phases of the cell cycle. The varying punctuate patterns of fluorescence, drastic changes in SNR, shape and position during mitosis and abundance of touching cells, however, require more sophisticated...
There is a great deal of interest in developing automated histological grading of tissue biopsies. Current approaches involve sophisticated algorithms for image segmentation, tissue architecture characterization, global texture feature extraction, and high-dimensional clustering and classification algorithms. Although overall image classification accuracy is measured, there has been very little attention...
Computer assisted or automated histological grading of tissue biopsies for clinical cancer care is a long-studied but challenging problem. It requires sophisticated algorithms for image segmentation, tissue architecture characterization, global texture feature extraction, and high-dimensional clustering and classification algorithms. Currently there are no automatic image-based grading systems for...
The large amount of data produced by biological live cell imaging studies of cell behavior requires accurate automated cell segmentation algorithms for rapid, unbiased and reproducible scientific analysis. This paper presents a new approach to obtain precise boundaries of cells with complex shapes using ridge measures for initial detection and a modified geodesic active contour for curve evolution...
Accurate vessel segmentation is the first step in analysis of microvascular networks for reliable feature extraction and quantitative characterization. Segmentation of epifluorescent imagery of microvasculature presents a unique set of challenges and opportunities compared to traditional angiogram-based vessel imagery. This paper presents a novel system that combines methods from mathematical morphology,...
Persistent object tracking in complex and adverse environments can be improved by fusing information from multiple sensors and sources. We present a new moving object detection and tracking system that robustly fuses infrared and visible video within a level set framework. We also introduce the concept of the flux tensor as a generalization of the 3D structure tensor for fast and reliable motion detection...
Quantifying the behavior of cells individually, and in clusters as part of a population, under a range of experimental conditions, is a challenging computational task with many biological applications. We propose a versatile algorithm for segmentation and tracking of multiple motile epithelial cells during wound healing using time-lapse video. The segmentation part of the proposed method relies on...
Detection and tracking of moving objects are the essential steps of many video understanding applications such as traffic monitoring, video surveillance and visual event recognition. Moving object detection process segments the scene into foreground (moving) and background regions. Moving cast shadows cause serious problems in this process because they can easily be misclassified as foreground. This...
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