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Patients with schizophrenia are at high risk for diabetes, dyslipidemia, hypertension, and obesity, which can be exacerbated by some atypical antipsychotics.To evaluate the effect of lurasidone on weight and metabolic parameters.To establish the cardiometabolic safety of lurasidone.Short-term data were pooled from seven, double-blind, 6-week studies of subjects with acute exacerbation of schizophrenia...
Atypical antipsychotics bind to multiple receptor types and subtypes. Improved outcomes in schizophrenia are linked to activity at D 2 and serotonin receptors 5-HT 7 , 5-HT 2A and 5-HT 1A .To characterize the receptor-binding profile of lurasidone and other antipsychotics.To compare receptor-binding profiles of antipsychotics.Replicated, side-by-side receptor-binding...
Contact-wire/onboard battery hybrid railway electric vehicles run on a hybrid power source that enables energy to be fed from contact wires and /or onboard batteries. We developed a contact-wire/battery hybrid LRV (Light Rail Vehicle) and had it manufactured. This paper concerns the hybrid source technology for the contact-wire/battery hybrid system, and on the running results with onboard rechargeable...
We developed novel energy-storage equipment that is series-connected to DC side of traction inverter of DC electric railway vehicle. When a train is powering and braking at a high-speed and the equipment boosts an input voltage of the traction inverter, the motor torque increases. Consequently, the mechanical brake force, compensating the electric brake force, becomes less. That leads to less energy...
Hybrid electric LRV can be defined as light rail electric vehicles fed by a contact feeder line (trolley, over head wire, third rail, and so on) as well as an on-board electrical energy storage device. We developed a tramcar with trolley-collection and on-board battery hybrid technology. This technology achieves 3 main features: 1) Energy consumption reduction 2) Trolley maintenance cost reduction...
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