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Nicotine, an addictive substance in cigarette, triggers glutamatergic synaptic plasticity on ventral tegmental area (VTA) dopamine (DA) neurons. The functional coupling between prefrontal cortex (PFC) and VTA has been demonstrated, but little is known how PFC mediates nicotinic modulation in VTA DA neurons. In this study, we tested the hypothesis that systemic exposure to nicotine significantly increases...
In this article, we investigate the influence of acute exposure to 2-aminoethoxy-diphenylborate (2-APB), a membrane-permeable inositol 1,4,5-trisphosphate (IP3) receptor, and store-operated Ca2+ channel (SOC) blocker on the complexity of hippocampal gamma oscillations. Our central hypothesis is that acute exposure to 2-APB significantly reduces the hippocampal gamma oscillations. To test this hypothesis,...
The laryngeal chemoreflex (LCR) develops in infants as a primary sensory mechanism for defending the airway from the aspiration of liquids. Previous studies have hypothesized that prolonged apnea associated with LCR may be life threatening and might be a cause of sudden infant death syndrome (SIDS). In this study we quantify the output of the respiratory neural network, the diaphragm EMG signal, during...
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