The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
We propose a web interface that allows researchers to quantify and analyze microtubule confocal images online. Most analyses of microtubule confocal images are performed manually using very simple software or tools. Analysis results are stored locally within each collaborator with different styles and formats. This has limited the sharing of data and results when collaborating among different research...
Microtubule (MT) dynamics quantification includes modeling of elongation, rapid shortening, and pauses. It indicates the effect of the cancer treatment drug paclitaxel because the drug causes MTs to bundle, which will in turn inhibit successful mitosis of cancerous cells. Thus, automatic MT dynamics analysis has been researched intensely because it allows for faster evaluation of potential cancer...
We propose a two dimensional model to simulate microtubule dynamics. Microtubules are polymers that are important in many cell functions including cell division. In particular, chemotherapy targets microtubule dynamics in order to slow cancer cell reproduction. Traditional stochastic or chemical models for microtubule dynamics are one-dimensional, focusing on one variable such as length or concentration...
A new method is proposed for tracking the dynamics of microtubules. It combines a salient point extraction mechanism for segmenting plus-end tips, a robust tracking method capable of locating the trajectories of a large number of feature points, and a classification algorithm capable of determining if the level of activity of a given microtubule video is typical of that of a treated or a control cell...
We propose to use particle filter [1], along with active contour [2] to track and model the plus-end tips of microtubules in confocal microscopy. Microtubules are polymers that change between states of growth, shortening, and pause. These events are critical to many cellular functions and are targets for successful cancer chemotherapy agents like Taxol. However, analyses are performed manually by...
Colorectal cancer, the second leading cause of cancer deaths in the United States, is a disease for which there are no known biomarkers of risk that can be used for predicting and preventing the disease. Based on new knowledge of the molecular basis of colorectal cancer, we developed and validated a panel of biomarkers of risk that can be measured in rectal biopsies. The goal of this work is to develop...
Microtubules (MT) are dynamic polymers that rapidly transition between states of growth, shortening, and pause. These dynamic events are critical for many microtubule functions such as intracellular trafficking and signaling. In addition, cancer chemotherapy drugs that target microtubules, such as the taxanes and the vinca alkaloids, are known to suppress microtubule dynamics at low doses, leading...
Colorectal cancer, the second leading cause of cancer deaths in the United States, is a molecular disease that is largely lifestyle determined and preventable. While heart disease has been sharply declining, in large part from widespread use of biological measurements that indicate risk ("biomarkers of risk"), such as blood cholesterol, to motivate and guide preventive treatment, colorectal...
Microtubules are dynamic polymers that rapidly transition between states of growth, shortening, and pause. These dynamic events are critical for basic cellular processes, especially cell division. Typically, these events are quantified by imaging microtubule movements over time, which results in large data sets that require rigorous quantitative analysis. In most cases, these analyses are performed...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.