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In the highly active antiretroviral therapy era, an increasingly large number of HIV-infected patients are developing non—AIDS-defining cancers (NADCs). As patients survive longer, long-term therapy—related complications take on greater importance. Herein, we describe a patient with AIDS who presented to medical attention with pancytopenia 48 months postchemotherapy with etoposide, prednisone, vincristine,...
A considerable volume of research exists concerning the domain of automatic planning and scheduling, hut many real-world scheduling problems, and especially that of transportation logistics, remain difficult to solve. In particular, this domain demands schedule-solving for every vehicle in a transportation fleet where pick-up and delivery of customer orders is distributed across multiple geographic...
The spindle checkpoint prevents chromosome loss by preventing chromosome segregation in cells with improperly attached chromosomes [1–3]. The checkpoint senses defects in the attachment of chromosomes to the mitotic spindle [4] and the tension exerted on chromosomes by spindle forces in mitosis [5–7]. Because many cancers have defects in chromosome segregation, this checkpoint may be required for...
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