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The main contribution of this work is a mathematical theorem which establishes a necessary and sufficient condition to preserve the behaviour of a genetic regulatory network when it is embedded into a larger network. We adopt the modelling approach of Ren´e Thomas, which provides a discrete representation of biological regulatory networks. This framework is entirely formalized using labelled graphs...
We present progress on a comprehensive, modular, interactive modeling environment centered on overall regulation of blood pressure and body fluid homeostasis. We call the project SAPHIR, for ";a Systems Approach for PHysiological Integration of Renal, cardiac, and respiratory functions";. The project uses state-of-the-art multi-scale simulation methods. The basic core model will give succinct...
We discuss current progress towards two complementary web resources being developed for the Renal Physiome: (1) a database (QKDB) for quantitative and anatomical data at all levels of kidney organization, including molecular-level information on membrane channels and transporters, structural and functional parameter values at the epithelial level, measured flows and concentrations along vessels and...
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