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Glioblastoma is the most aggressive form of brain cancer. Transcriptional aberrations may play an important role in etiology of glioblastoma, which might be caused through genomic alterations: nucleotide mutation, copy number variation, DNA mythelation. Here, we explored another possible mechanism involving cooperative deregulation of microRNAs (miRNAs) and transcription factors (TFs). Several miRNA-TF...
Clozapine and its four related drugs (olanzapine, quetiapine, risperidone and ziprasidone) are the most frequently used treatments for schizophrenia in the world. The underlying mechanisms are not well understood. In this study, we investigated the features of these five drugs through their related genes at the pathway level. For each drug, we first identified pathways that the drugs might be involved...
Schizophrenia is a major brain-related mental disorder. Many genes are likely associated with schizophrenia; their gene-gene interactions as well as gene-environment interactions may contribute as a major risk to the disorder. Rather than the traditional studies of single gene or marker, in this study we hypothesized that positional candidate genes under linkage peaks may play a major role in causing...
Schizophrenia is a heritable complex disease that involves multiple genes interacting themselves or with environment. Its genetic mechanisms have not been well understood. Currently, studies have revealed hundreds of genes associated with schizophrenia. This provides us an opportunity to explore the molecular characteristics of schizophrenia genes (SCZGenes) using genomics and systems biology approaches...
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