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Background Cleft palate (CP) is the second most common congenital birth defect; however, the relationship between CP-associated genes and epigenetic regulation remains largely unknown. In this study, we investigated the contribution of microRNAs (miRNAs) to cell proliferation and regulation of genes involved in CP development. Methods In order to identify all genes for which mutations or association/linkage...
Wnt signaling pathway is involved in multiple cell processes including cell differentiation, cell development, and cell fate. Mutations in the Wnt pathway genes have been frequently found to cause cancer. Recently, there has been emerging evidence showing that abnormality of the Wnt pathway may also be involved in neurogenesis and synaptic plasticity; thus, it may play important roles in psychotic...
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