Joseph Glorioso

Chronic pain is often difficult to treat effectively. We have exploited the high affinity of herpes simplex virus (HSV) for peripheral sensory neurons to create HSV-based vectors for the treatment of chronic pain. We have demonstrated that an HSV-based vector expressing proenkephalin reduces pain-related responses in rodent models of inflammatory pain, neuropathic pain, and pain resulting from cancer...

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Therapeutic gene transfer with herpes-based vectors: studies in Parkinson's disease and motor nerve regeneration

David J. Fink, Joseph Glorioso, Marina Mata

Experimental Neurology > 2003 > 184 > Supplement 1 > 19-24

We have examined the possibility of using herpes simplex virus (HSV)-based vectors to prevent neuronal cell death and enhance functional recovery after injury. In the 6-hydroxydopamine (6-OHDA) model of Parkinson's disease (PD) and after proximal spinal root injury, direct stereotactic injection of HSV-based vectors constructed to express the glial cell derived neurotrophic factor (GDNF) or the anti-apoptotic...

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American society of gene therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells

Donald B. Kohn, Michel Sadelain, Cynthia Dunbar, David Bodine, more

Molecular Therapy > 2003 > 8 > 2 > 180-187

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Bcl-2 and GDNF Delivered by HSV-Mediated Gene Transfer Act Additively to Protect Dopaminergic Neurons from 6-OHDA-Induced Degeneration

Atsushi Natsume, Marina Mata, James Goss, Shaohua Huang, more

Experimental Neurology > 2001 > 169 > 2 > 231-238

Previous studies have demonstrated that either the neurotrophin glial-derived neurotrophic factor (GDNF) or the antiapoptotic peptide Bcl-2 delivered into striatum by a viral vector protects dopaminergic neurons of the substantia nigra in vivo from degeneration induced by the administration of the neurotoxin 6-hydroxydopamine (6-OHDA). In this study we used recombinant, replication-incompetent, genomic...

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Herpes Simplex Virus Vector-Mediated Expression of Bcl-2 Protects Spinal Motor Neurons from Degeneration Following Root Avulsion

Masanobu Yamada, Atsushi Natsume, Marina Mata, Thomas Oligino, more

Experimental Neurology > 2001 > 168 > 2 > 225-230

Proximal axotomy in adult animals results in delayed death of motor neurons. Features characteristic of both necrosis and apoptosis have been described in motor neurons of the spinal cord following proximal avulsion of the ventral roots. We have previously demonstrated that a genomic herpes simplex virus (HSV)-based vector expressing the anti-apoptotic peptide Bcl-2 protects dopaminergic neurons of...

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Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors

Michele Simonato, Roberto Manservigi, Peggy Marconi, Joseph Glorioso

Trends in Neurosciences > 2000 > 23 > 5 > 183-190

The use of viral vectors to transfect genes into specific brain-cell populations is a novel approach that can be used to investigate the molecular and cellular basis of brain function. Ideal vectors should be targetable and capable of regulated transgene expression. From the viral vectors developed so far, this article focuses on herpes simplex virus 1 (HSV-1)-based vectors. HSV-1 vectors can be engineered...

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Search results for: Joseph Glorioso

PD01-02 GENE THERAPY WITH REPLICATION-DEFICIENT HERPES SIMPLEX VIRUS (HSV) VECTORS ENCODING PORELESS TRPV1 (PL) OR PROTEIN PHOSPHATASE 1α (PP1α) IN A RAT MODEL OF HYDROGEN PEROXIDE-INDUCED CYSTITIS

MP30-04 HERPES SIMPLEX VIRUS (HSV) VECTOR-MEDIATED GENE DELIVERY OF PORELESS TRPV1 CHANNELS OR PROTEIN PHOSPHATE 1α (PP1α) REDUCES BLADDER OVERACTIVITY AND NOCICEPTION IN RAT MODEL OF CYSTITIS INDUCED BY HYDROGEN PEROXIDE

PD20-05 HERPES SIMPLEX VIRUS (HSV) VECTOR-MEDIATED GENE DELIVERY OF PROTEIN PHOSPHATASE 1α REDUCES BLADDER OVERACTIVITY AND

MP1-03 HERPES SIMPLEX VIRUS (HSV) VECTOR-MEDIATED GENE DELIVERY OF PROTEIN PHOSPHATASE 1α REDUCES BLADDER OVERACTIVITY AND NOCICEPTION IN RATS

1038 ENKEPHALIN GENE THERAPY USING A HERPES SIMPLEX VIRUS VECTOR SUPPRESSES CYTOKINE ELEVATION IN THE BLADDER AND URINE OF RATS WITH CYSTITIS

A Platform for Gene Delivery to Embryonic Stem Cells Using HSV

641. Development of a Selectable HSV Replication System Based on Calcium Influx Cytotoxicity Mediated by Expression and Activation of TRPV1

640. A Novel Herpes Simplex Virus Vector Expressing Endomorphin-2: Characterization and Antinociceptive Properties

Development of HSV-mediated gene transfer for the treatment of chronic pain

Therapeutic gene transfer with herpes-based vectors: studies in Parkinson's disease and motor nerve regeneration

American society of gene therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells

Bcl-2 and GDNF Delivered by HSV-Mediated Gene Transfer Act Additively to Protect Dopaminergic Neurons from 6-OHDA-Induced Degeneration

Herpes Simplex Virus Vector-Mediated Expression of Bcl-2 Protects Spinal Motor Neurons from Degeneration Following Root Avulsion

Gene transfer into neurones for the molecular analysis of behaviour: focus on herpes simplex vectors

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INFONA - science communication portal

Search results for: Joseph Glorioso

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