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In an effort to broaden the immune response induced by the RTS,S/AS02 A ,vaccine, we have evaluated the immunogenicity of the RTS,S antigen when combined with MSP1 42 and with AMA1, antigens derived from the asexual blood stage. The objectives of this study were (i) to determine whether MSP1 42 and AMA1 vaccines formulated with the AS02 A Adjuvant System were safe and...
The Escherichia coli RecA protein has served as a model for understanding protein-catalyzed homologous recombination, both in vitro and in vivo. Although RecA proteins have now been sequenced from over 60 different bacteria, almost all of our structural knowledge about RecA has come from studies of the E. coli protein. We have used electron microscopy and image analysis to examine three different...
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