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Mathematical modeling of tumor response to radiotherapy has the potential of enhancing the quality of the treatment plan, which can be even tailored on an individual basis. Lack of extensive in vivo validation has prevented, however, reliable clinical translation of modeling outcomes. Image-guided radiotherapy is a consolidated treatment modality based on computed tomographic (CT) imaging for tumor...
Mathematical modeling of the tumor response to radiotherapy may provide a meaningful contribution to enhance the therapeutic planning and adjust the treatment on the run. Clinical translation of modeling results is currently prevented by the lack of sufficient validation on a patient-specific basis while imaging techniques along with the latest treatments (e.g. IGRT) can make available a large number...
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