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Apoptotic processes, or the disturbance of the natural regulation of these processes, may be involved in the pathogenesis of autoimmune diseases (AID). Women are, in general, more susceptible than men to develop AID like rheumatoid arthritis. Androgens and glucocorticoids, in contrast to oestrogens, have favourable effects in AID models as well as in human AID. It is known that glucocorticoids (GC),...
Introduction: Dehydroepiandrosterone (DHA) is a naturally occuring steroid with immunostimulating activities probably caused by its 7α-OH metabolites. Inflammatory cytokines IL-1 and TNFα stimulate non-lymphoid cells to an increased formation of 7αOH-DHA. It was investigated whether conversion of DHA into 7αOH-DHA occurs in thymus and spleen and whether this conversion is caused by a specific enzyme...
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