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A case report of a 16-year-old boy with the classical form of phenylketonuria (PKU) and suffering from a delusional disorder is presented. He did not respond to a traditional antipsychotic medication but improved on an atypical antipsychotic, risperidone. The cerebrospinal fluid metabolites of the biogenic amines were measured and are also reported in the context of a recent interest in the ratios...
Plasma GABA, which is a peripheral index of brain GABA activity, is low in a subset of about 40% of adults with major depressive and bipolar disorders. It is not known whether this biological marker of mood disorder is a consequence or scar of illness or represents an antecedent vulnerability. We measured plasma GABA in 14 healthy control adolescents with no history of psychiatric disorder in...
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