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Live oral rotavirus vaccines that are effective in middle and high income countries have been much less immunogenic and effective among infants in resource-limited settings. Several hypotheses might explain this difference, including neutralization of the vaccine by high levels of maternal antibody in serum and breast milk, severe malnutrition, and interference by other flora and viruses in the gut...
We evaluated serum and fecal antibody responses to bovine norovirus (BoNoV) virus-like particles (VLP) and protection against virulent BoNoV in gnotobiotic calves. Calves were vaccinated with two or three doses of VLPs (250μg/dose) coadministered with oil, mutant E. coli heat-labile toxin (R192G) (mLT) or immunostimulating complexes (ISCOM). Fecal IgA antibody was detected only in calves vaccinated...
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