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Stimulation of muscarinic receptors is known to have a biphasic effect on colonic Cl − secretion: a short-lasting activation, which is followed by a long-lasting inhibition. In order to find out, which role G q proteins play in both processes, Pasteurella multocida toxin was used, a known activator of Gα q . This toxin (1.5 µg/ml) had a dual action on short-circuit current...