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The short-term effect of dietary squalene (SQ) tocotrienols (T3) and α-tocopherol (T) on serum and liver cholesterol levels was investigated in the hamster. Our results show that dietary squalene (0.1%) lowered serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) levels as compared with the control palm oil triacylglycerol (POTG)...
Male guinea pigs were treated intraperitoneally with different dosages of tocotrienols isolated from palm oil fatty acid distillate (PFAD) for 6 consecutive days. Control animals were treated with vitamin E-free palm oil triglycerides. Commercial animal pellets and water were given ad libitum during the treatment period. The guinea pigs were sacrificed at around 2400 hr. Liver HMG CoA reductase was...
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