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Vitamin B12 acts as a coenzyme of enzymatic reactions, particularly in the biosynthesis of deoxyribonucleic acid. Its deficiency can induce a macrocytic megaloblastic anaemia. We have studied the performances of the immunoenzymatic assay CEDIA (Cloned enzyme donor immunoassay, Boehringer), by comparison to RIA (Chiron Diagnostics). Within-run imprecision is correct for both methods. On the contrary,...