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Innovative polymeric controlled release inhalable dry powders containing dexamethasone were developed for the treatment of pulmonary diseases. Powders were prepared in one step by vibrational atomization spray-drying using an organic solution containing dexamethasone, poly(ε-caprolactone) and a surfactant. The characteristics of the powders were monitored considering the drug content, morphological...
The aim of the present study was to develop a transdermal system for controlled delivery of melatonin combining three strategies: nanoencapsulation of melatonin, drying of melatonin-loaded nanocapsules, and incorporation of nanocapsules in a hydrophilic gel. Nanocapsules were prepared by interfacial deposition of the polymer and were spray-dried using water-soluble excipients. In vitro drug release...
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