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Hydrogen sulfide is well known to regulate multiple physiological aspects of vascular function including vasodilation, inflammation, and growth responses that may become dysfunctional during ischemia. However, specific sulfide metabolism responses during chronic vascular ischemia remain poorly understood. Recent work from our laboratory reveals that permanent vascular ischemia due to ligation and...
Recent studies indicate that hydrogen sulfide and nitric oxide metabolites may interact biochemically or by targeting similar molecular pathways. However, the relationship between hydrogen sulfide and nitric oxide bioavailability remains poorly understood, as well as possible biological effects of combined H 2 S/NO treatment. A prospective clinical observational study was performed to examine...