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Innate immune responses are crucial for host defense against pathogens but need to be tightly regulated to prevent chronic inflammation. Initial characterization of mice with a targeted inactivating mutation in the p110δ subunit of phosphoinositide 3-kinase (PI3K p110δ D910A/D910A ) revealed defects in B- and T-cell signaling and chronic colitis. Here, we further characterize features of inflammatory...
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