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Aviscumine, a recombinant plant protein, inactivates the 28S rRNA (“ribotoxic stress”) after endocytosis. In this way cytokine release and T-cell responses are enhanced. This phase II trial was conducted to test the efficacy and safety of aviscumine in pts with systemically pre-treated metastatic melanoma stage IV.32 pts with Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 were...