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Since its initial clinical use in 1980, anti-TCR/CD3 monoclonal antibody (mAb) has been shown to be a potent immunosuppressive agent in the prevention of renal allograft rejections. However, toxic side effects caused by release of cytokines, predominantly from activated CD4 + T-cells, remain a major problem with the use of these reagents. Previous work has shown that this activation is mediated...
The ability of retinoids to regulate interleukin-2 receptor (IL-2R) levels on human T-cells may play a fundamental role in the immunomodulating effects of these compounds. As a cell line model for studying this phenomenon, we tested the effects of retinoic acid (RA) on the expression of IL-2Rα and IL-2Rβ in Hut78 cells, a mature T-cell line derived from a Sezary T-cell leukemia. Our results demonstrated...
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