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Missense mutations of the S182 gene (presenilin 1) in chromosome 14 and STM2 gene (presenilin 2) in chromosome 1 are causative of some of autosomal dominant familial Alzheimer's disease. They are believed to have an important role on APP processing. For the first step to understand the function of presenilin and the relationship to amyloid Aβ formation, we investigated histochemical localization...