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Preoperative administration of pregabalin is proposed as a promising way of enhancing postoperative pain control. Whereas a few studies have investigated the effect of pregabalin on postoperative opioid consumption, no study has focused on the influence on postoperative hyperalgesia. In this randomized, triple-blinded, placebo-controlled study, we aimed to demonstrate that a single, preoperative dose...
Zahlreiche Studien geben Hinweise darauf, dass Pregabalin antihyperalgetische Eigenschaften besitzt, welche potenziell auch perioperativ genutzt werden könnten. Pregabalin bewirkt durch Bindung am Kalziumkanal eine verminderte Abgabe exzitatorischer Neurotransmitter und in weiterer Folge eine Hemmung der zentralen Sensibilisierung. In zahlreichen Tierversuchen konnte diese antihyperalgetische Potenz...
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