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Transcription rate as a key factor determining productivity of a cell line is a function of promoter strength and accessibility as well as the number of expression units. This simple logic was the rationale for gene amplification strategies that have been applied extensively in the past but lost attractivity mainly due to substantial time requirements. However, multiple copies are not limited to gene...
Complex therapeutic glycoproteins are typically produced in mammalian cells. The development of pharmaceutical cell lines is an unpredictable and time-consuming effort, requiring the identification of rare clones which combine integration of the transgenes into highly active genomic loci with superior folding, processing and secretion capabilities. Further, this intensive investment has to...
The complete DNA sequence and transcription map of human adenovirus type 11 are reported here. This is the first published sequence for a subgenera B human adenovirus and demonstrates a genome organization highly similar to those of other human adenoviruses. All of the genes from the early, intermediate, and late regions are present in the expected locations of the genome for a human adenovirus. The...
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