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To assess the duration of antiviral prophylaxis (AP), we conducted a retrospective outbreak review over 3 seasons, looking for acute respiratory illness (ARI) onset after 5 days of AP. Of 114 facility-level outbreaks with 352 unit-level outbreaks, we found only 1 case of laboratory-confirmed influenza after 5 days of AP. New cases of ARI after 5 days of AP should be investigated, and recommendations...