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Estrogen receptor α (ERα) is a member of a large conserved superfamily of steroid hormone nuclear receptors which regulates many physiological pathways by acting as a ligand-dependent transcription factor. Evidence is emerging that estrogens also induce rapid signaling to the downstream kinase cascades; however the mechanisms underlying this nongenomic function remain poorly understood. We have recently...
In this work, we used colon carcinoma cell-line HCT116 to study the involvement of the 86-kDa subunit (Ku86) of DNA-protein kinase (DNA-PK) in human tumoural cell proliferation. We transfected these cells with a 639-bp cDNA encoding a Ku86 portion inserted into pcDNA3.1 vector in the antisense orientation. After selection by neomycin, we obtained more than 300 resistant colonies. In the Y'A5 colony...
Objectif de l'etude. - Ku86 est un gene essentiel implique dans la reparation des cassures double-brin de l'ADN et la radiosensibilite chez les rongeurs. Cependant, son role dans les cellules humaines est moins bien connu. L'objectif de cette etude etait d'evaluer la radiosensibilite, la cinetique de reparation des cassures double-brin de l'ADN apres transfection d'un antisens de KU86 dans une lignee...
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