The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Interferon-β (IFN-β) is a key component of cellular innate immunity in mammals, and it constitutes the first line of defence during viral infection. In vitro studies showed that almost all nucleated cells are able to produce IFN-β to various extents, but information about the in vivo source of IFN-β remains incomplete. Since prominent IFN producer cells such as plasmacytoid dendritic cells are usually...
Before starting to work with a genetically modified pathogen in a laboratory, risks associated with its genetic modification must be assessed. This can be a difficult task, particularly when the modified organism has a highly variable genome. A remarkable example for this is influenza A virus. Influenza viruses are notorious for their genetic variability. These viruses can easily switch between hosts...
In mice, influenza virus resistance is strongly dependent on the interferon (IFN)-regulated Mx1 gene which encodes a potent restriction factor that inhibits a poorly defined early step of the viral life cycle. Humans possess two IFN-regulated Mx genes with antiviral activity. The human Mx1 gene (encoding MxA protein) confers resistance to a broad range of RNA viruses in cell culture, including influenza...
Mx proteins are interferon (IFN)-induced GTPases that confer antiviral activity in many vertebrates. Mouse Mx1 accumulates in the nucleus of IFN-treated cells and mediates antiviral activity in vitro and in vivo against orthomyxoviruses, such as influenza A and Thogoto viruses. Human MxA is a cytoplasmic protein that exhibits an even broader antiviral activity in cultured cells. However, to date,...
Mononuclear phagocytes are an important component of an innate immune system perceived as a system ready to react upon encounter of pathogens. Here, we show that in response to microbial stimulation, mononuclear phagocytes residing in nonmucosal lymphoid organs of germ-free mice failed to induce expression of a set of inflammatory response genes, including those encoding the various type I interferons...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.