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Absence of pain and loss of consciousness are the most striking characteristics of anesthesia and anesthesia-like states such as concussion, reversible coma, syncope (fainting). These states also exhibit movement inhibition, amnesia, a shift to delta-wave EEG pattern, and depressed cerebral metabolism. It is generally presumed that this constellation of signs reflects widely distributed suppression...
General anesthetics are presumed to act in a distributed manner throughout the CNS. However, we found that microinjection of GABA A -receptor (GABA A -R) active anesthetics into a restricted locus in the rat brainstem, the mesopontine tegmental anesthesia area (MPTA), rapidly induces a reversible anesthesia-like state characterized by suppressed locomotion, atonia, anti-nociception...
Pentobarbital microinjected into a restricted locus in the upper brainstem induces a general anesthesia-like state characterized by atonia, loss of consciousness, and pain suppression as assessed by loss of nocifensive response to noxious stimuli. This locus is the mesopontine tegmental anesthesia area (MPTA). Although anesthetic agents directly influence spinal cord nociceptive processing, antinociception...
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