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Adaptive immunity requires the generation of memory T cells from naive precursors selected in the thymus. The key intermediaries in this process are stem cell-like memory T (TSCM) cells, multipotent progenitors that can both self-renew and replenish more differentiated subsets of memory T cells. In theory, antigen specificity within the TSCM pool may be imprinted statically as a function of largely...
► General method to identify the determinants of protective immunity and its application to HTLV-1. ► Observation made that “innate” KIR receptors enhance the HLA class I-restricted response in HTLV-1 infection. ► Description of the mechanisms of HTLV-1 persistence and of the importance of the viral protein HBZ. ► Observation made that CD8+ T cells kill infected, Tax-expressing cells in vivo at a...
The herb layer of forests planted on former agricultural land often differs from that of old-growth forest. This study investigates if the expected increased nutrient availability in the shaded conditions of newly planted forests and the plasticity of the species to adjust their biomass allocation to different levels of light and nutrients help to explain these differences in the herb layers of the...
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