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Consistent pathological hallmarks of Alzheimer's disease (AD) are the formation of brain amyloid and neurofibrillary tangles (NFTs). Levels of the major protein component of NFTs, the microtubule associated protein Tau, were shown to be increased in cerebrospinal fluid (CSF) of AD patients as compared to age-matched controls. The presence of the apolipoprotein E–ϵ4 allele (APOE4) is a risk factor...
Amyloid deposits in Alzheimer's disease are composed of amyloid β-peptides (Aβ) that are derived from the larger amyloid precursor protein (APP). Proteolytic APP processing is activity-dependent, and it can be regulated by muscarinic acetylcholine receptors. In particular, muscarinic m1 receptor subtypes increase cleavage within the Aβ domain, followed by the release of the soluble APP ectodomain...
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