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Twist proteins have been shown to contribute to cancer development and progression by impinging on different regulatory pathways, but their mechanism of action is poorly defined. By investigating the role of Twist in sarcomas, we found that Twist1 acts as a mechanism alternative to TP53 mutation and MDM2 overexpression to inactivate p53 in mesenchymal tumors. We provide evidence that Twist1 binds...
In vitro measurements of sunscreen products are used to assess their reliability in terms of photoprotection and photo-stability.In this study, several substrates have been fully characterized for in vitro sunscreen testing.The following different substrates have been utilised in the study: roughened PMMA plates, Transpore, Vitro-Skin, roughened quartz plate and a laboratory prepared roughened PTFE...
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