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The present descriptive study shows the expression pattern of an mRNA, IIIG9, whose most striking expression is seen along the lining of all four ventricles of the adult rat brain. Lower levels of expression are evident in other areas of the brain, notably in cortex, hippocampus, and various thalamic, hypothalamic and brainstem nuclei where it seems to be primarily neuronal, with little or no expression...
Dentatorubral-pallidoluysian atrophy (DRPLA) is a neurodegenerative disease that results from the expansion of an unstable CAG repeat within the coding regions of the DRPLA gene. Recently it was shown that the DRPLA gene product, atrophin-1, interacts with the human insulin receptor tyrosine kinase substrate protein, IRSp53. We have isolated rat and mouse cDNA clones for IRSp53 and determined expression...
Cortistatin is a 14-residue putative neuropeptide with strong structural similarity to somatostatin and is expressed predominantly in cortical GABAergic interneurons of rats. Administration of cortistatin into the brain ventricles specifically enhances slow-wave sleep, presumably by antagonizing the effects of acetylcholine on cortical excitability. Here we report the identification of cDNAs corresponding...
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