Search results for: Cong-Fei Xu

Items from 1 to 15 out of 15 results

article

Long‐Term Storage Stable Vesicle‐Like Nanoparticles of Lipid and Polymer for siRNA and mRNA‐Mediated Cancer Immunotherapy

Chaoran Chen, Yuxi Zhang, Ziyang Cao, Dongdong Li, more

Advanced Functional Materials > 34 > 44 > n/a - n/a

RNA‐based therapeutics have emerged as a promising strategy for cancer immunotherapy, encompassing the silencing of immune checkpoint genes, chimeric antigen receptor T (CAR‐T) cell production, and antitumor vaccines. Despite their tremendous potential, the urgent need for the development of clinically applicable delivery systems remains paramount. In this study, vesicle‐like nanoparticles (VNPs)...

article

Rigid Shell Decorated Nanodevice with Fe/H₂O₂ Supply and Glutathione Depletion Capabilities for Potentiated Ferroptosis and Synergized Immunotherapy

Xu Dai, Yueqiang Zhu, Miao Su, Junbin Chen, more

Advanced Functional Materials > 33 > 27 > n/a - n/a

The overexpressed glutathione peroxidase4 (GPX4) and insufficient H₂O₂ in tumor cells weaken ferroptosis therapy and the elicited anticancer immune response. Herein, a rigid metal‐polyphenol shell decorated nanodevice ssPPE_Lap@Fe‐TA is constructed to successfully overcome the drawbacks of ferroptosis therapy. The ssPPE_Lap@Fe‐TA consists of a rigid Fe‐TA network‐based shell and disulfide‐containing...

article

Development of “CLAN” Nanomedicine for Nucleic Acid Therapeutics

Cong‐Fei Xu, Shoaib Iqbal, Song Shen, Ying‐Li Luo, more

Small > 15 > 16 > n/a - n/a

Nucleic acid‐based macromolecules have paved new avenues for the development of therapeutic interventions against a spectrum of diseases; however, their clinical translation is limited by successful delivery to the target site and cells. Therefore, numerous systems have been developed to overcome delivery challenges to nucleic acids. From the viewpoint of clinical translation, it is highly desirable...

article

Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell intervention

Min Li, Ya-Nan Fan, Zhi-Yao Chen, Ying-Li Luo, more

Nano Research > 2018 > 11 > 12 > 6270-6282

B cells exert multiple effector functions, and dysfunctions of B cells often lead to initiation and progression of diseases, including autoimmune and inflammatory diseases. Therefore, B cell intervention may be an effective strategy to treat diseases involving B cells. The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene editing system has been widely used for DNA deletion,...

article

Responsive Nanocarriers as an Emerging Platform for Cascaded Delivery of Nucleic Acids to Cancer

Yang Liu, Cong-Fei Xu, Shoaib Iqbal, Xian-Zhu Yang, more

Advanced Drug Delivery Reviews > 2017 > 115 > C > 98-114

Cascades of systemic and intracellular obstacles, including low stability in blood, little tumor accumulation, weak tumor penetration, poor cellular uptake, inefficient endosomal escape and deficient disassembly in the cytoplasm, must be overcome in order to deliver nucleic acid drugs for cancer therapy. Nanocarriers that are sensitive to a variety of physiological stimuli, such as pH, redox status,...

article

Nanoparticle-facilitated autophagy inhibition promotes the efficacy of chemotherapeutics against breast cancer stem cells

Rong Sun, Song Shen, Yun-Jiao Zhang, Cong-Fei Xu, more

Biomaterials > 2016 > 103 > C > 44-55

Cancer stem cells (CSCs) have garnered increasing attention over the past decade, as they are believed to play a crucial role in tumor initiation, progression and metastasis, relapse and drug resistance. Therapeutic strategies which simultaneously exterminate both bulk tumor cells and the rare CSC subpopulation may produce striking response and result in long-term tumor remission. Accumulating evidence...

article

Restoring anti-tumor functions of T cells via nanoparticle-mediated immune checkpoint modulation

Shi-Yong Li, Yang Liu, Cong-Fei Xu, Song Shen, more

Journal of Controlled Release > 2016 > 231 > C > 17-28

The core purpose of cancer immunotherapy is the sustained activation and expansion of the tumor specific T cells, especially tumor-infiltrating cytotoxic T lymphocytes (CTLs). Currently, one of the main foci of immunotherapy involving nano-sized carriers is on cancer vaccines and the role of professional antigen presenting cells, such as dendritic cells (DCs) and other phagocytic immune cells. Besides...

article

Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery

Cong-Fei Xu, Hou-Bing Zhang, Chun-Yang Sun, Yang Liu, more

Biomaterials > 2016 > 88 > C > 48-59

The design of ideal nanoparticle delivery systems should be capable of meeting the requirements of several stages of drug delivery, including prolonged circulation, enhanced accumulation and penetration in the tumor, facilitated cellular internalization and rapid release of the active drug in the tumor cells. However, among the current design strategies, meeting the requirements of one stage often...

article

Facile Generation of Tumor‐pH‐Labile Linkage‐Bridged Block Copolymers for Chemotherapeutic Delivery

Chun‐Yang Sun, Yang Liu, Jin‐Zhi Du, Zhi‐Ting Cao, more

Angewandte Chemie > 128 > 3 > 1022 - 1026

Successful bench‐to‐bedside translation of nanomedicine relies heavily on the development of nanocarriers with superior therapeutic efficacy and high biocompatibility. However, the optimal strategy for improving one aspect often conflicts with the other. Herein, we report a tactic of designing tumor‐pH‐labile linkage‐bridged copolymers of clinically validated poly(d,l‐lactide) and poly(ethylene glycol)...

article

Facile Generation of Tumor‐pH‐Labile Linkage‐Bridged Block Copolymers for Chemotherapeutic Delivery

Chun‐Yang Sun, Yang Liu, Jin‐Zhi Du, Zhi‐Ting Cao, more

Angewandte Chemie International Edition > 55 > 3 > 1010 - 1014

article

Targeting glucose uptake of glioma cells by siRNA delivery with polymer nanoparticle

Cong-fei Xu, Yang Liu, Song Shen, Yan-hua Zhu, more

Journal of Controlled Release > 2015 > 213 > C > e23-e24

article

Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells

Rong Sun, Yang Liu, Shi-yong Li, Song Shen, more

Journal of Controlled Release > 2015 > 213 > C > e94

article

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy

Cong-Fei Xu, Yang Liu, Song Shen, Yan-Hua Zhu, more

Biomaterials > 2015 > 51 > C > 1-11

Targeting cancer metabolism is emerging as a successful strategy for cancer therapy. However, most of the marketed anti-metabolism drugs in cancer therapy do not distinguish normal cells from cancer cells, leading to severe side effects. In this study, we report an effective strategy for cancer therapy through targeting glucose transporter 3 (GLUT3) with siRNA-based nanomedicine to simultaneously...

article

Delivery systems for siRNA drug development in cancer therapy

Cong-fei Xu, Jun Wang

Asian Journal of Pharmaceutical Sciences > 2015 > 10 > 1 > 1-12

Since the discovery of the Nobel prize-winning mechanism of RNA interference (RNAi) ten years ago, it has become a promising drug target for the treatment of multiple diseases, including cancer. There have already been some successful applications of siRNA drugs in the treatment of age-related macular degeneration and respiratory syncytial virus infection. However, significant barriers still exist...

article

Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells

Rong Sun, Yang Liu, Shi-Yong Li, Song Shen, more

Biomaterials > 2015 > 37 > C > 405-414

Combination treatment through simultaneous delivery of two or more drugs with nanoparticles has been demonstrated to be an elegant and efficient approach for cancer therapy. Herein, we employ a combination therapy for eliminating both the bulk tumor cells and the rare cancer stem cells (CSCs) that have a high self-renewal capacity and play a critical role in cancer treatment failure. All-trans-retinoic...

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