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Triterpenoid saponins are secondary metabolites showing a remarkable structural variety, as well as notable biological activities. They are synthesised via the isoprenoid pathway by 2,3-oxidosqualene cyclization mediated by oxidosqualene cyclase (OSC) enzymes. In our previous work, three new oleanane-type triterpene saponins (astersedifolioside A–C) were isolated from the aerial tissues of Aster sedifolius...
The plant pathogenesis-related protein osmotin is an antifungal cytotoxic agent that causes rapid cell death in the yeast S. Cerevisiae. We show here that osmotin uses a signal transduction pathway to weaken defensive cell wall barriers and increase its cytotoxic efficacy. The pathway activated by osmotin includes the regulatory elements of the mating pheromone response STE4, STE18, STE20, STE5, STE11,...
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