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Industry experience suggests that g‐forces sustained when vials containing protein formulations are accidentally dropped can cause aggregation and particle formation. To study this phenomenon, a shock tower was used to apply controlled g‐forces to glass vials containing formulations of two monoclonal antibodies and recombinant human growth hormone (rhGH). High‐speed video analysis showed cavitation...
The design of biodegradable polymeric delivery systems based on polyanhydrides that would provide for improved structural integrity of Yersinia pestis antigens was the main goal of this study. Accordingly, the full-length Y. pestis fusion protein (F1–V) or a recombinant Y. pestis fusion protein (F1 B2T1 –V10) was encapsulated and released from microparticles based on 1,6-bis(p-carboxyphenoxy)hexane...
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