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Purpose: Vascular access dysfunction is a major cause of morbidity and hospitalization in the hemodialysis population. In the United States, $1 billion per year is spent managing the vascular complications of hemodialysis. Venous neointimal hyperplasia (VNH), with subsequent venous stenosis and thrombosis at the graft-vein anastomosis, constitutes 75% of failed polytetrafluoroethylene vascular grafts...
Prostaglandins play an important role in the initiation and/or maintenance of labor. In the fetal membranes, the regulatory pathways and mechanism of activation of prostaglandin synthesis is complex and not clearly defined. Human amnion-derived WISH cells respond to many mitogens, cytokines and growth factors with elevated production of prostaglandin E 2 which is partially mediated by the...
Prostaglandins play an important role in the initiation and/or maintenance of labor. The mechanisms which regulate activation of prostaglandin production in amnion are complex and poorly defined. The lipid body has been identified in neutrophils and other inflammatory cells as a site to which substrate and enzymes are localized, creating a single compartment within the cell for efficient production...
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