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We have used gene targeted mutational approaches to assess the role of the T cell receptor α (TCRα) enhancer (Eα) in the control of TCRα and TCRδ gene rearrangement and expression. We show that Eα functions in cis to promote Vα to Jα rearrangement across the entire Jα locus, a distance of greater than 70 kb. We also show that Eα is required for normal αβ T cell development; in this lineage, Eα is...
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