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Mycobacterium tuberculosis secreted proteins in culture filtrate and early phase of infection, such as early secretory antigen target 6 (ESAT-6), culture filtrate protein 10 (CFP-10), and antigen 85 complex i.e. Ag85A, Ag85B, and Ag85C which played roles in adherence, invasion, cytolysis, and evading cytosol of macrophage, were virulence factors that determined the immune responses important on pathogenesis...
Mycobacterium tuberculosis (MTB), the main causative organism of tuberculosis (TB), is a successful pathogen that overcomes the numerous challenges presented by the immune system of the host. The situation regarding control of tuberculosis has significantly worsened over the last decade with the spread of strains resistant to multiple antimycobacterial agents. Mycobacterial cell wall has potential...
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