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Barnase has been co-crystallized at neutral pH with its natural product the 3'-guanylic acid. The X-ray structure was solved by molecular replacement methods and refined to a final R-factor of 18.7%. The protein folding is essentially the same as that of the native form. The base recognition site is almost identical to that of the homologous binase-3'GMP complex, but the nucleotide is bound in a productive...