Search results for: Mariagrazia Marucci

Items from 1 to 14 out of 14 results

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New insights on the influence of manufacturing conditions and molecular weight on phase-separated films intended for controlled release

Helene Andersson Moore, Mariagrazia Marucci, Linda Härdelin, Johan Hjärtstam, more

International Journal of Pharmaceutics > 2018 > 536 > 1 > 261-271

The aim of this work was to investigate how manufacturing conditions influence phase-separated films of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) with different molecular weights of HPC. Two HPC grades, SSL and M, with weight average molecular weights (M_w) of 30×10³g/mol and 365×10³g/mol, respectively, were combined with EC 10 cps (70:30w/w EC/HPC) and spray-coated from ethanol solutions...

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A three-dimensional anisotropic point process characterization for pharmaceutical coatings

Henrike Häbel, Tuomas Rajala, Mariagrazia Marucci, Catherine Boissier, more

Spatial Statistics > 2017 > 22 > P2 > 306-320

Spatial characterization and modeling of the structure of a material may provide valuable knowledge on its properties and function. Especially, for a drug formulation coated with a polymer film, understanding the relationship between pore structure and drug release properties is important to optimize the coating film design. Here, we use methods from image analysis and spatial statistics to characterize...

article

Determination of the release mechanism of Theophylline from pellets coated with Surelease®—A water dispersion of ethyl cellulose

Jurgita Kazlauske, Maria Margherita Cafaro, Diego Caccavo, Mariagrazia Marucci, more

International Journal of Pharmaceutics > 2017 > 528 > 1-2 > 345-353

The aim of this study was to investigate the water transport over free standing films based on the aqueous ethyl cellulose (EC) coating Surelease^® and the drug (Theophylline) release mechanism from coated pellets. It was found that the main drug release rate from pellets was controlled by a diffusion mechanism. However, the drug release rate was altered by addition of sodium chloride to the external...

article

New insights on how to adjust the release profile from coated pellets by varying the molecular weight of ethyl cellulose in the coating film

Mariagrazia Marucci, Helene Andersson, Johan Hjärtstam, Gary Stevenson, more

International Journal of Pharmaceutics > 2013 > 458 > 1 > 218-223

The major aims of this work were to study the effect of the molecular weight (Mw) of ethyl cellulose (EC) on the drug release profile from metoprolol succinate pellets coated with films comprising EC and hydroxypropyl cellulose (HPC) with a weight ratio of 70:30, and to understand the mechanisms behind the different release profiles. A broad range of Mws was used, and the kinetics of drug release...

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Effect of the manufacturing conditions on the structure and permeability of polymer films intended for coating undergoing phase separation

Mariagrazia Marucci, Johan Arnehed, Annica Jarke, Hanna Matic, more

European Journal of Pharmaceutics and Biopharmaceutics > 2013 > 83 > 2 > 301-306

The major aim of this work was to study the effect of two process parameters, temperature and coating flow, on permeability to water and structure of free films sprayed from mixtures of ethyl cellulose (EC), hydroxypropyl cellulose (HPC), and ethanol. The films were sprayed in a new spraying setup that was developed to mimic the film coating process in a fluid bed and to provide well controlled conditions...

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Mechanistic modelling of drug release from polymer-coated and swelling and dissolving polymer matrix systems

Erik Kaunisto, Mariagrazia Marucci, Per Borgquist, Anders Axelsson

International Journal of Pharmaceutics > 2011 > 418 > 1 > 54-77

The time required for the design of a new delivery device can be sensibly reduced if the release mechanism is understood and an appropriate mathematical model is used to characterize the system. Once all the model parameters are obtained, in silico experiments can be performed, to provide estimates of the release from devices with different geometries and compositions. In this review coated and matrix...

article

Dissolution kinetics or pure mass transfer? A mechanistic study of dissolution

Erik Kaunisto, Mariagrazia Marucci, Anders Axelsson

AIChE Journal > 57 > 10 > 2610 - 2617

In many cases, classic in vitro tests are used to investigate dissolution from powders and solids. A problem with these kinds of tests is the frequent use of agitation, leading to a lumped description of the properties at the solid–liquid interface. The hydrodynamic forces arising from agitation might have a nontrivial impact on the dissolution properties, thus calling for a comparison of results...

article

Polymer leaching from film coating: Effects on the coating transport properties

Mariagrazia Marucci, Gert Ragnarsson, Christian von Corswant, Anette Welinder, more

International Journal of Pharmaceutics > 2011 > 411 > 1-2 > 43-48

The release mechanism of metoprolol succinate pellets coated with a blend of a water-insoluble polymer, ethyl cellulose (EC), and a water-soluble polymer, hydroxypropyl cellulose (HPC), is mechanistically explained. The kinetics of drug release and HPC leaching were followed for drug doses. The coating was initially not permeable to the drug, and release started only after a critical amount of the...

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Osmotic pumping release from ethyl–hydroxypropyl–cellulose-coated pellets: A new mechanistic model

Mariagrazia Marucci, Gert Ragnarsson, Bernt Nilsson, Anders Axelsson

Journal of Controlled Release > 2010 > 142 > 1 > 53-60

A new mechanistic model of drug release by osmotic pumping and diffusion from pellets coated with a semipermeable film developing pores created by the leaching of water-soluble compounds initially present in the coating, has been developed. The model describes dynamically all the main processes occurring during release, i.e. the inflow of solvent driven by the difference in osmotic pressure across...

article

Coated formulations: New insights into the release mechanism and changes in the film properties with a novel release cell

Mariagrazia Marucci, Johan Hjärtstam, Gert Ragnarsson, Frida Iselau, more

Journal of Controlled Release > 2009 > 136 > 3 > 206-212

The effect of the blend ratio of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC-LF), on the properties of sprayed films and on the drug release mechanism of formulations coated with the material was investigated. When the original HPC-LF content exceeded 22%, both the amount of HPC-LF leached out and the water permeability of the films increased drastically when...

article

The use of holographic interferometry and electron speckle pattern interferometry for diffusion measurement in biochemical and pharmaceutical engineering applications

Anders Axelsson, Mariagrazia Marucci

Optics and Lasers in Engineering > 2008 > 46 > 12 > 865-876

In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparation...

article

Mechanistic model for drug release during the lag phase from pellets coated with a semi-permeable membrane

Mariagrazia Marucci, Gert Ragnarsson, Ulf Nyman, Anders Axelsson

Journal of Controlled Release > 2008 > 127 > 1 > 31-40

A new mechanistic model of drug release during the lag phase from coated pellets undergoing cracking in the coating due to the hydrostatic pressure built up inside the pellet has been developed. The model describes dynamically all the main release processes occurring during the lag phase in pellets coated with a semi-permeable membrane, i.e. the influx of solvent driven by the difference in osmotic...

article

Evaluation of osmotic effects on coated pellets using a mechanistic model

Mariagrazia Marucci, Gert Ragnarsson, Anders Axelsson

International Journal of Pharmaceutics > 2007 > 336 > 1 > 67-74

The aim of this study was to develop a simple experimental methodology and to develop a mechanistic model to characterize the release mechanism from pellets developing cracks during the release process with special focus on osmotic effects. The release of remoxipride from pellets coated with an ethyl cellulose film was chosen as a case study. Dose release experiments at different bulk osmotic pressures...

article

Electronic speckle pattern interferometry: A novel non-invasive tool for studying drug transport rate through free films

Mariagrazia Marucci, Gert Ragnarsson, Anders Axelsson

Journal of Controlled Release > 2006 > 114 > 3 > 369-380

In this work, Electronic Speckle Pattern Interferometry (ESPI) is presented as a non-invasive tool to study drug transport in controlled release systems. ESPI is shown to be a feasible tool to measure drug film permeability via comparison with an ordinary diaphragm cell. A specially designed cuvette was used in the release study: the polymeric film separated the donor and the receiving chambers of...

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