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Transplantation across HLA antibody barriers is associated with an increased risk for early antibody mediated rejection (AMR). Post-transplant monitoring of donor specific HLA-antibody (DSA) is critical to allow for effective anti-rejection intervention. In this HLA incompatible case, we sought to determine whether HLA-C1q data provides additional information regarding the deleterious nature of the...
Clinical studies have demonstrated that HLA-DP-specific antibodies can be detrimental to a transplanted kidney. The number of patients affected is proportional to the frequency of DP antibodies. We determined the frequency of HLA-DP-specific antibodies en toto and in the absence of cross-reactive DR antibodies. Of 650 waitlisted renal patients, 271 (42%) were reactive with HLA-DP antigens in solid-phase...
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