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Experimental Autoimmune Encephalomyelitis (EAE) is a pre-clinical disease model of Multiple Sclerosis (MS), traditionally induced by injecting Myelin Oligodendrocyte Glycoprotein(MOG). Optic nerve involvement and VEP diagnostic reliability have been already shown in MOG induced EAE rat. In the present study we used spinal cord homogenate (SCH) to induce disease in Dark-Agouti (DA) rats, proposing...
Experimental autoimmune encephalomyelitis (EAE) is a pre-clinical disease model of Multiple Sclerosis (MS). In the present study we used a novel emulsion derived from the spinal cord – spinal cord homogenate (SCH) – to induce disease in Dark-Agouti (DA) rats, monitoring EAE course by using Visual Evoked Potentials (VEPs) to assess their usefulness as neurophysiological biomarker. 19 DA rats were used...