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Evidence for management of asthma comes from closely monitored efficacy trials done in highly selected patient groups. There is a need for randomised trials that are closer to usual clinical practice. We did an open-label, randomised, controlled, two-arm effectiveness trial at 74 general practice clinics in Salford and South Manchester, UK. Patients aged 18 years or older with a general practitioner's...
The reaction of DNBP (2,4-dinitro-6-sec-butylphenol) with toluene, ethylbenzene or styrene and tert-butylperoxide at 110°C leads to 7-sec-butyl-5-nitro-2-phenylbenzoxazole. This benzoxazole was also detected in the residues of an industrial styrene fractionation still in which DNBP was routinely used as the polymerisation retarder. The formation of this product from either ethyl benzene or from...
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