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Despite use of polyelectrolytes is considered to be a prospective approach of protein aggregation suppression, owing to formation of soluble protein-polyelectrolyte complexes, the structure of the complexes and mechanism of their formation are not sufficiently understood. The aim of this work was to study the influence of degree of polymerization on the structure and properties of formed complexes...
This data is related to our paper “Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress” (Lazarev et al. [1]) where we explore therapeutic properties of small molecules preventing GAPDH aggregation in cell and rat models of oxidative stress. The present article demonstrates a few of additional properties of the chemicals shown to block...
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is one of the most abundant targets of the oxidative stress. Oxidation of the enzyme causes its inactivation and the formation of intermolecular disulfide bonds, and leads to the accumulation of GAPDH aggregates and ultimately to cell death. The aim of this work was to reveal the ability of chemicals to break the described above pathologic linkage by...
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